First Synthesis of 3-Acetyl-2-aminothiophenes Using the Gewald Reaction

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First synthesis of 3-acetyl-2-aminothiophenes using the Gewald reaction.

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and 1,4-dithianyl-2,5-diols using a modified Gewald reaction. The syntheses of the corresponding acetamides, as well as that of 3-acetyl-2-amino-5-nitrothiophene - an interesting building-block for thiophene azo dyes - are reported. Detailed spectroscopic investigations ((1)H-NMR, (13)C-NMR, MS, IR) of the obtained compounds are p...

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ژورنال

عنوان ژورنال: Molecules

سال: 2006

ISSN: 1420-3049

DOI: 10.3390/11050371